how it works
The Cause of Wrinkles
As you age, your natural levels of collagen drop which causes wrinkles in your skin. Put simply, the less collagen available within your skin, the more wrinkles that you will develop.
How Your Skin Functions
To understand how Entre Derm’s™ creams help reduce wrinkles, it is first important to understand how your skin retains collagen and why it lets smaller molecules such as water out, while keeping larger molecules such as collagen in. Like a net, your skin allows small molecules, such as salts, out when you perspire. The skin also allows water to escape in order to keep you cool. However, larger molecules, such as collagen, are too big to pass through this net – hence they remain inside the skin where they belong.
How Your Skin Retains Collagen
Collagen is a much larger molecule than water. If your body simply allowed collagen to escape through your skin, you would lose all of it in your infancy. Fortunately, your body is good at keeping larger molecules inside – therefore your collagen is retained and depletes slowly as you age. However, just as your skin functions to prevent larger molecules from escaping, the same system makes it a challenge to enable larger molecules to enter the skin as well. As a result, trying to inject additional collagen into your skin in order to reduce wrinkles has historically always required a needle.
The Entre Derm™ Advantage For Providing Collagen
Entre Derm's™ unique advantage is the patent pending Somazone™ process. The Somazone™ process allows molecules to actually squeeze through the tight space of your skin cells, bringing with it ingredients that could not get through by themselves. What makes Somazone™ so unique is the weight of the ingredients it can bring directly through the skin's surface. This means that Somazone™ can enable larger molecules to enter into your skin – without the need for a needle! This includes an abundance of anti-aging ingredients such as collagen, ceramides and hyaluronic acid that can be delivered to the skin. Saturated with these revitalizing ingredients – the skin immediately looks younger and healthier – youthful contours are restored, wrinkles are softened and smoothed and it helps to achieve a flawless clarity and radiant glow.
The Science of Somazone™ To Deliver Collagen
Somazone™ is a process that utilizes a biopolymer. It is the result of years of research in transdermal delivery. In Entre Derm™ Skincare's Night and Day Creams, active ingredients such as collagen, are attached to the Somazone™ molecule which enables the direct delivery of these ingredients through the surface of the skin. Somazone™ allows large molecules to squeeze through the outer layers of skin and be delivered to where they are vitally needed. In Entre Derm™ Skincare's Night and Day Creams, active ingredients such as collagen, utilizes the Somazone™ process which enables the direct delivery of these ingredients through the surface of the skin.
Patent Pending Technology Behind Somazone™
The technology behind Somazone™ was originally developed from research into the transdermal delivery of insulin for diabetics. Our parent company, Transdermal Sciences PLC, holds a patent for this transdermal drug delivery system. Somazone™ is our patent-pending process that combines this biopolymer backbone with active ingredients. Somazone's™ interdermal delivery of these ingredients, such as collagen, ceramides and hyaluronic acid, ushers in a future of increased effectiveness to the world of cosmetics. Entre Derm™ Skincare is proud to bring the power of biotechnology, the power of Somazone™, into the field of anti-aging research.
Clinical Trials:
Two sets of clinical trials have been conducted. The first was at a leading University and the second was performed by Stephens & Co., an independent firm that specializes in product safety evaluation and toxicology based in Dallas.
Both trials were double blind randomized studies, with a placebo (a leading competitive product) applied on one side of the face and Entre Derm™ Night Cream on the other. The trial lasted 4 weeks and a representative sample of women completed the clinical studies.
The women in the first study were scheduled to undergo facial plastic surgery and Entre Derm™ was applied to those portions of the skin to be removed. The skin was biopsied before and after the trial and the results analyzed by an independent pathologist. The trial demonstrated that the collagen ingredient had been transported to the skin.
In the second study, 20 women were also treated with Entre Derm™ Night Cream and a placebo. The results of the test showed that the side of the face treated with Entre Derm™ was less wrinkled, presented better pigmentation, felt smoother and was fresher looking.
Patents:
Patents for the Somazone™ delivery technology have been applied for in the United States and Internationally for the non-irritating formulation of the Entre Derm™ product and are pending at this time.
The following is a copy of the Abstract filed with the patent applications:
"This invention describes a composition of matter to facilitate intra-dermal delivery of a great
variety of active substances, especially including high molecular weight cosmeceutical. Also
disclosed is a method of forming the composition of matter and applying topically to patients,
especially using a cream or patch. The active substance is initially combined with a biopolymer,
which combination, is subsequently linked to a base formulation whereby the base formulation
aids in the intra-dermal delivery of the active substance without the skin irritation limitations of
other formulations and dermal transmitting methods. The use of a combination of natural herbal,
vegetable and animal products combined in this invention with biopolymers permits molecules
of higher molecule weight to penetrate into the skin in a bioactive form by passive delivery
means. The invention includes a product for, the improvement of skin health and wrinkle reduction."
Entre Derm™ featuring the unique Somazone™ technology is a breakthrough in the science of cosmetics as it delivers what your skin needs to help in the anti-aging process.
Entre Derm™ – where Science delivers Beauty!
Clinical Evaluation - Overall % Improvement
